2009 Genetics and Genomics Pilot Feasibility Grant Program - 3rd Round
Co-sponsored by the Endowment for the Basic Sciences (EBS) and the Center for Genetics in Health and Medicine (CGHM)
The Genetics and Genomics Pilot Feasibility Grant Program is designed to foster new collaborations on campus between members of the University of Michigan faculty from distinct disciplines to focus their combined research strengths on cutting-edge areas in genetics and genomics. We will provide supporting funds for new research projects that utilize high throughput genetic analysis tools including DNA Sequencing, a newly acquired Illumina Bead Station 500GX, an Illumina 1G Genome Analyzer (formerly Solexa), a Roche 454-FLX Genome Sequencer and array scanning technology.
Investigators and Co-Investigators who have full-time University of Michigan instructional, research or clinical track faculty positions are eligible to apply. Proposals may be in any area of basic, clinical, translational or epidemiological research and should represent a new research effort that will lead to external funding. Utilization of new technologies is not required. All areas of genetics and genomics research will be considered.
PI's may submit only one application. PI's of current Genetics and Genomics pilot feasibility grants are not eligible to apply.
Applications available on-line July 9, 2009
Application deadline is September 9, 2009, 11:00 p.m. EDT
Grant funds available in February 2010
Applications must be submitted on-line.
Proposals should be for one year of support, with requested funding up to $30,000. Funds may not be used for travel expenses or equipment. Faculty salaries are allowed expenses, but costs cannot exceed $10,000 (including fringe benefits). Cost sharing is encouraged. Each proposal will receive peer review by a group of recognized experts in the area of the proposal. Review criteria will include:
- Scientific merit.
- Feasibility (i.e. availability of research samples for high throughput genetic analysis and appropriate plans for biostatistics and bioinformatics analyses).
- Likelihood of future external funding.
- Innovation and collaboration (i.e. projects that launch new initiatives).
Grant proposals should include:
- Title of project, project period and amount requested.
- Abstract (250 words).
- Proposal Narrative (in pdf format):
- 5 pages max, single-spaced with spaces between paragraphs, 11 point Arial font, including text, figures, tables and references. Organized as follows:
- Specific Aims: no more than ½ page.
- Rationale, motivation, and preliminary findings.
- Research plan, explicitly tied to Specific Aims.
- Nature of the collaboration of the complementary PIs.
- Relationship of the proposed work to current funding.
- Work plan with timeline to credible high-probability funding proposal to NIH (or other specific funding agency).
- Budget and budget justification (Download form).
For assistance with budgeting for high throughput technologies please see http://seqcore.brcf.med.umich.edu and/or contact Dr. Robert Lyons.
- Standard 4-page PHS 398 biosketch for each investigator (Download blank template) (Download Instructions).
INCOMPLETE APPLICATIONS & THOSE THAT EXCEED THE PAGE LIMIT GUIDELINES WILL NOT BE ACCEPTED.
Application Submission Deadline: Wednesday Sept. 9, 2009 11:00 p.m. EDT
Current CGHM Pilot Feasibility awardees:
- James Engel (PI), David Ginsburg, M.D. (Co-PI) - "Identity and abundance of DRED repressor target sites and target genes during human erythroid cellular differentiation"
- Tom Glaser - "Identification of Hereditary Anophthalmia and Retinal Nonattachment Genes"
- Tom Glover (PI), Tom Wilson (Co-PI) - "High-resolution analysis of sporadic and induced genomic copy number alterations"
- Aaron Goldstrohm (PI), Trista Schagat (Co-PI), James Cavalcoli (Co-PI) - "Identification of mRNAs regulated by human PUF proteins using high throughput sequencing"
- Stephen Gruber (PI), Peter Gruber (Co-PI), Jun Li (Co-PI) - "Individual Genome Sequencing to Identify the Genetic Basis of Hypoplastic Left Heart Syndrome in a Unique Kindred"
- Jeff Innis (PI), Friedhelm Hildebrandt (Co-PI) - "Identification of the Gene for Urofacial (Ochoa) Syndrome"
- Catherine Keegan (PI) - "Using next generation sequencing to identify the Danforth's short tail mouse mutation"
- John Kim (PI), Jun Li (Co-PI) - "Comprehensive detection of human microRNA genetic variants in a worldwide population panel"
- Jun Li (PI), Noah Rosenberg (Co-PI) - "Resequencing-based analysis of population diversity and evolution of human X chromosome genes"
- Jiandie Lin (PI), Zhaohui Qin (Co-PI) - "ChIP-Seq Analysis of Transcriptional Coactivator PGC-1a; in the Control of Circadian Energy Metabolism in the Liver"
- Yang Liu (PI), Steve Qin (Co-PI) - "Global Analysis of Selection of T Cell Repertoire by Sequencing of T Cell Receptor Beta-Chain CDR3"
- Donna Martin (PI), Jun Li (Co-PI) - "Microarray Capture and Rapid Sequencing to Find the Molecular Cause of Martin-Probst Syndrome, an X-linked Disorder Affecting Hearing, Cognition, Craniofacial Development, Somatic Growth, and Aging"
- Sean Morrison (PI), John V. Moran (Co-PI) - "Forward Genetics Analysis Of Stem Cell Self-Renewal Using Transposon Mutagenesis"
- Steve Qin (PI), Goncalo Abecasis (Co-PI), James Elder (Co-PI), Rajan Nair (Co-PI) -"Targeted resequencing study of seven new psoriasis candidate genes"
- Diane Robins (PI), Jun Li (Co-PI) - "Development of RNA-tag-Seq, a Novel Approach to High-throughput Sequencing, to Probe Androgen Receptor Function in a Mouse Model of Prostate Cancer"
- Jessica Schwartz (PI), Steve Qin (Collaborator) - "Use of ChIP-Seq to identify target genes in a novel transcriptional repressor-activator relationship regulated by growth hormone"
- Audrey Seasholtz (PI), Robert C. Thompson (Co-PI), Fan Meng (Co-PI) - "Analysis of Corticosteroid Receptor Homodimer and Heterodimer Target Genes in Hippocampus by ChIP-Seq."
- Christiane Wobus (PI), Vincent Young (Co-PI) - "16S genetic analysis of the gastrointestinal microbiome following enteric norovirus infection"
- Vincent Young (PI), Gary Huffnagle (Co-PI) - "High-throughput 16S genetic analysis of the gastrointestinal microbiome"
If you have questions regarding the application process, please contact:
For technical problems with the online application or website, please email: